The gut microbiome and T cells in celiac disease

In celiac disease, T cells that recognize proteins from wheat, barley, and rye (gluten) cause inflammation in the gut. However, wit is unclear what triggers this inflammation. In this study, researchers at the University of Minnesota are trying to understand if differences in intestinal bacteria correspond to differences in these T cells in healthy individuals compared to those with celiac disease. This is a non-interventional study where we are collecting duodenal fluid (aspirates), duodenal biopsies, blood, and fecal samples to track these differences.

Interested in participating in celiac research studies? Reach out to celiac@umn.edu for more information.